Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
USERS' SCORE
Good
Based on 10 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E (as d-alpha Tocopherol)
268 mg
1787%
Top Medical Research Studies
9
Potential atheroprotective effects of T3
We aimed to explore how pure tocotrienol (T3), a form of vitamin E, might help in fighting atherosclerosis, a condition often linked to high cholesterol. In our study, 30 rabbits were fed high-cholesterol diets and then divided into groups receiving different doses of T3 or a control without T3.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
Read More
8
Tocopheryl quinone benefits high cholesterol
We examined how tocopheryl quinone, a form of vitamin E, impacts high cholesterol in rats fed a high-fat diet linked to liver disease. Our findings showed that while these rats had increased cholesterol levels, tocopheryl quinone treatment was able to reverse these effects.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
Read More
8
We explored how alpha-tocopherol, a form of vitamin E, affects the development of nonalcoholic steatohepatitis (NASH) in rabbits fed a high-cholesterol diet. Our study revealed that without alpha-tocopherol, rabbits experienced significant inflammation and liver damage linked to NASH. However, supplementing with alpha-tocopherol effectively reduced these harmful inflammatory responses and damage, showing promise in protecting against NASH development. Interestingly, while alpha-tocopherol helped lower the inflammatory signals and apoptosis in liver cells, it did not alter cholesterol levels or fat accumulation in the liver.
Read More
Most Useful Reviews
9
Lowers blood pressure
33 people found this helpful
After stopping Vitamin E for three years, I noticed my blood pressure rise significantly. I resumed taking it and my systolic pressure returned to normal within two days. This Vitamin E is fantastic for maintaining healthy arteries and overall heart health as we age.
Read More
9
Convenient vitamin format
2 people found this helpful
This Vitamin E combines both E-400 and different tocopherols in one capsule, making dosage straightforward. My doctor recommended mixed tocopherols for their broader health benefits, despite a higher cost compared to pure vitamin E. It appears to positively affect my overall health.
Read More
9
Skin improvement
1 people found this helpful
I’ve taken these vitamin E capsules for a few months and love their quality. They protect cells from oxidative stress and support heart health. I’ve noticed my skin feels more hydrated, and the mixed tocopherols provide broader benefits.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
- All Researches
9
Potential atheroprotective effects of T3
We aimed to explore how pure tocotrienol (T3), a form of vitamin E, might help in fighting atherosclerosis, a condition often linked to high cholesterol. In our study, 30 rabbits were fed high-cholesterol diets and then divided into groups receiving different doses of T3 or a control without T3.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
The results were promising, showing that the lower and higher doses of T3 significantly reduced atherosclerotic markers and inflammation in early and established atherosclerosis compared to the control group. This suggests that T3 may play a valuable role alongside standard treatments in preventing coronary artery disease.
Read More
8
We investigated how a high cholesterol diet impacts male fertility by activating stress in testicular cells, leading to cell death. Using rabbits as our model, we found that this diet noticeably increased apoptosis in the testicular tubules. However, when we supplemented the rabbits' diets with α-tocopherol, a form of vitamin E, we observed a remarkable reduction in this cholesterol-induced cell death. This suggests that vitamin E might serve as a protective agent against damage caused by high cholesterol, helping to preserve testicular health.
Read More
8
Tocopheryl quinone benefits high cholesterol
We examined how tocopheryl quinone, a form of vitamin E, impacts high cholesterol in rats fed a high-fat diet linked to liver disease. Our findings showed that while these rats had increased cholesterol levels, tocopheryl quinone treatment was able to reverse these effects.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
Read More
8
We explored how alpha-tocopherol, a form of vitamin E, affects the development of nonalcoholic steatohepatitis (NASH) in rabbits fed a high-cholesterol diet. Our study revealed that without alpha-tocopherol, rabbits experienced significant inflammation and liver damage linked to NASH. However, supplementing with alpha-tocopherol effectively reduced these harmful inflammatory responses and damage, showing promise in protecting against NASH development. Interestingly, while alpha-tocopherol helped lower the inflammatory signals and apoptosis in liver cells, it did not alter cholesterol levels or fat accumulation in the liver.
Read More
8
Vitamin E aids in cholesterol reduction
We explored the impact of combined treatment with hepatoprotectors and an antioxidant preparation of vitamins A and E on patients experiencing non-alcoholic steatohepatitis (NASH) after the Chornobyl disaster.
Our study involved 72 patients, examining biochemical blood analyses and liver structures.
The results were promising, showing improvements in antioxidant levels and a decrease in cholesterol levels, suggesting that vitamin E treatment could effectively restore metabolic balance and support liver health.
Our study involved 72 patients, examining biochemical blood analyses and liver structures.
The results were promising, showing improvements in antioxidant levels and a decrease in cholesterol levels, suggesting that vitamin E treatment could effectively restore metabolic balance and support liver health.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Lowers blood pressure
33 people found this helpful
After stopping Vitamin E for three years, I noticed my blood pressure rise significantly. I resumed taking it and my systolic pressure returned to normal within two days. This Vitamin E is fantastic for maintaining healthy arteries and overall heart health as we age.
Read More
9
Convenient vitamin format
2 people found this helpful
This Vitamin E combines both E-400 and different tocopherols in one capsule, making dosage straightforward. My doctor recommended mixed tocopherols for their broader health benefits, despite a higher cost compared to pure vitamin E. It appears to positively affect my overall health.
Read More
9
Skin improvement
1 people found this helpful
I’ve taken these vitamin E capsules for a few months and love their quality. They protect cells from oxidative stress and support heart health. I’ve noticed my skin feels more hydrated, and the mixed tocopherols provide broader benefits.
Read More
7.5
Cholesterol management
1 people found this helpful
I’ve used NOW Natural E-400 for years. It seems to control my cholesterol levels, which my doctor confirms is good. I initially took it for heart protection, and I’m pleased with the results. NOW Foods remains my favourite brand for its quality and reasonable prices.
Read More
8
Supports heart health
2 people found this helpful
After researching the Shute brothers' findings, I chose this for heart health. I'm keen to prevent high cholesterol and other heart issues. This product meets my needs for a natural tocopherol supplement.
Read More
Frequently Asked Questions
9
Lowers blood pressure
33 people found this helpful
After stopping Vitamin E for three years, I noticed my blood pressure rise significantly. I resumed taking it and my systolic pressure returned to normal within two days. This Vitamin E is fantastic for maintaining healthy arteries and overall heart health as we age.
7.5
Cholesterol management
1 people found this helpful
I’ve used NOW Natural E-400 for years. It seems to control my cholesterol levels, which my doctor confirms is good. I initially took it for heart protection, and I’m pleased with the results. NOW Foods remains my favourite brand for its quality and reasonable prices.
7.5
Positive results
1 people found this helpful
I began taking vitamin E to help lower my high cholesterol alongside other medications. I’m seeing positive results so far, and the quality-to-price ratio is excellent.
9
Skin improvement
1 people found this helpful
I’ve taken these vitamin E capsules for a few months and love their quality. They protect cells from oxidative stress and support heart health. I’ve noticed my skin feels more hydrated, and the mixed tocopherols provide broader benefits.
7.5
Anti-aging benefits
1 people found this helpful
Vitamin E is my top vitamin! Its strong antioxidant effect is vital for anti-aging and health. It helps balance hormones in women, improving menstrual issues and conceiving chances. I take it post-dinner, and while it has a unique smell, it’s easy to swallow. Using it with vitamin C seems to boost its effects.
9
Convenient vitamin format
2 people found this helpful
This Vitamin E combines both E-400 and different tocopherols in one capsule, making dosage straightforward. My doctor recommended mixed tocopherols for their broader health benefits, despite a higher cost compared to pure vitamin E. It appears to positively affect my overall health.
7.5
Improves vessel elasticity
2 people found this helpful
Vitamin E is crucial in preventing blood clots and maintaining vessel elasticity, slowing cholesterol plaque formation. It is essential for reproductive health, and Now Foods consistently delivers high-quality supplements. The capsules are small and easy to take.
8
Tocopheryl quinone benefits high cholesterol
We examined how tocopheryl quinone, a form of vitamin E, impacts high cholesterol in rats fed a high-fat diet linked to liver disease. Our findings showed that while these rats had increased cholesterol levels, tocopheryl quinone treatment was able to reverse these effects.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
We noted improvements in gut health and reductions in harmful inflammatory markers after treatment. However, the study focused on a specific animal model, so results may not directly apply to humans.
Overall, tocopheryl quinone appears promising in addressing cholesterol issues related to liver complications.
8
We explored how alpha-tocopherol, a form of vitamin E, affects the development of nonalcoholic steatohepatitis (NASH) in rabbits fed a high-cholesterol diet. Our study revealed that without alpha-tocopherol, rabbits experienced significant inflammation and liver damage linked to NASH. However, supplementing with alpha-tocopherol effectively reduced these harmful inflammatory responses and damage, showing promise in protecting against NASH development. Interestingly, while alpha-tocopherol helped lower the inflammatory signals and apoptosis in liver cells, it did not alter cholesterol levels or fat accumulation in the liver.
7
Vitamin E's limited cholesterol impact
We explored how vitamin E might influence high cholesterol's impact on atherosclerosis, a condition where plaques build up in arteries. The study focused on how vitamin E affects endoplasmic reticulum (ER) stress, which is linked to this plaque formation.
While vitamin E showed potential in reducing ER stress caused by a high-cholesterol diet, it didn’t significantly improve cholesterol levels or reduce atherosclerosis. Overall, the results highlight vitamin E's complex interactions but indicate no major breakthroughs in cholesterol management.
While vitamin E showed potential in reducing ER stress caused by a high-cholesterol diet, it didn’t significantly improve cholesterol levels or reduce atherosclerosis. Overall, the results highlight vitamin E's complex interactions but indicate no major breakthroughs in cholesterol management.
2
Vitamin E treatment ineffective for cholesterol
We conducted a well-designed study involving 240 individuals with elevated LDL cholesterol to see if a combination of tocotrienols and polymethoxylated flavones could reduce cholesterol levels. Participants were placed in a double-blind, placebo-controlled setup, comparing the treatment against a placebo.
After 12 weeks, we found no significant differences in LDL cholesterol levels or high-sensitivity C-reactive protein levels between the groups. While all groups experienced some decrease in LDL cholesterol, it was not enough to demonstrate a true benefit from the supplements.
After 12 weeks, we found no significant differences in LDL cholesterol levels or high-sensitivity C-reactive protein levels between the groups. While all groups experienced some decrease in LDL cholesterol, it was not enough to demonstrate a true benefit from the supplements.
References
- Sozen E, Demirel-Yalciner T, Koroglu MK, Elmas MA, Ercan F, et al. High cholesterol diet activates ER stress mediated apoptosis in testes tissue: Role of α-tocopherol. IUBMB Life. 2022;74:85. doi:10.1002/iub.2535
- Sun T, Zhang B, Ru QJ, Chen XM, Lv BD. Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) restoring the balance of intestinal flora in rats. Pharm Biol. 2021;59:723. doi:10.1080/13880209.2021.1916542
- Demirel-Yalciner T, Sozen E, Ozaltin E, Sahin A, Ozer NK. alpha-Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis. Biofactors. 2021;47:403. doi:10.1002/biof.1700
- Bozaykut P, Ekren R, Sezerman OU, Gladyshev VN, Ozer NK. High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E. Biofactors. 2020;46:653. doi:10.1002/biof.1635
- Sarkisova EA, Chumak AA, Ovsyannikova LM, Alekhina LM, Nosach OV, et al. THE EFFECT OF APPLICATION OF ANTIOXIDANT THERAPY IN THE TREATMENT OF NON-ALKOHOLIC STEATOHEPATATIS IN CHORNOBYL NPP ACCIDENT SUFFERERS IN THE REMOTE PERIOD AFTER IRRADIATION. Probl Radiac Med Radiobiol. 2018;23:452. doi:10.33145/2304-8336-2018-23-452-461
- Sozen E, Yazgan B, Sahin A, Ince U, Ozer NK. High Cholesterol Diet-Induced Changes in Oxysterol and Scavenger Receptor Levels in Heart Tissue. Oxid Med Cell Longev. 2018;2018:8520746. doi:10.1155/2018/8520746
- Farràs M, Fernández-Castillejo S, Rubió L, Arranz S, Catalán Ú, et al. Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial. J Nutr Biochem. 2018;51:99. doi:10.1016/j.jnutbio.2017.09.010
- Libinaki R, Vinh A, Tesanovic-Klajic S, Widdop R, Gaspari T. The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice. Clin Exp Pharmacol Physiol. 2017;44 Suppl 1:107. doi:10.1111/1440-1681.12821
- Rahman TA, Hassim NF, Zulkafli N, Muid S, Kornain NK, et al. Atheroprotective effects of pure tocotrienol supplementation in the treatment of rabbits with experimentally induced early and established atherosclerosis. Food Nutr Res. 2016;60:31525. doi:10.3402/fnr.v60.31525
- Bumrungpert A, Pavadhgul P, Kalpravidh RW. Camellia Oil-Enriched Diet Attenuates Oxidative Stress and Inflammatory Markers in Hypercholesterolemic Subjects. J Med Food. 2016;19:895. doi:10.1089/jmf.2016.3659
- Apostolidou C, Adamopoulos K, Lymperaki E, Iliadis S, Papapreponis P, et al. Cardiovascular risk and benefits from antioxidant dietary intervention with red wine in asymptomatic hypercholesterolemics. Clin Nutr ESPEN. 2015;10:e224. doi:10.1016/j.clnesp.2015.08.001
- Katsarou AI, Kaliora AC, Chiou A, Kalogeropoulos N, Papalois A, et al. Amelioration of oxidative and inflammatory status in hearts of cholesterol-fed rats supplemented with oils or oil-products with extra virgin olive oil components. Eur J Nutr. 2016;55:1283. doi:10.1007/s00394-015-0947-5
- Schuchardt JP, Heine S, Hahn A. A combination of palm oil tocotrienols and citrus peel polymethoxylated flavones does not influence elevated LDL cholesterol and high-sensitivity C-reactive protein levels. Eur J Clin Nutr. 2015;69:1209. doi:10.1038/ejcn.2015.44
- Busso D, Mascareño L, Salas F, Berkowitz L, Santander N, et al. Early onset intrauterine growth restriction in a mouse model of gestational hypercholesterolemia and atherosclerosis. Biomed Res Int. 2014;2014:280497. doi:10.1155/2014/280497
- Bento AP, Cominetti C, Simões Filho A, Naves MM. Baru almond improves lipid profile in mildly hypercholesterolemic subjects: a randomized, controlled, crossover study. Nutr Metab Cardiovasc Dis. 2014;24:1330. doi:10.1016/j.numecd.2014.07.002
- Hobbs T, Caso R, McMahon D, Nymark M. A novel, multi-ingredient supplement to manage elevated blood lipids in patients with no evidence of cardiovascular disease: a pilot study. Altern Ther Health Med. 2014;20:18.
